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June 1965

Penetration of 14C Hydrocortisone Through Normal Skin: The Effect of Stripping and Occlusion

Author Affiliations


From the Division of Dermatology, University of California, San Francisco Medical Center, San Francisco, Calif, (Dr. Feldmann and Dr. Maibach).

Arch Dermatol. 1965;91(6):661-666. doi:10.1001/archderm.1965.01600120093023

Between 0.2 and 1.0 per cent of hydrocortisone, applied to normal skin appears in the urine over a period of ten days. Stripping the skin doubles this amount and significantly alters the absorption rate curve. An occlusive dressing increases absorption ten-fold but does not basically alter the absorption rate curve. Evidence is presented suggesting that both the stratum corneum and the Malpighian/basal layers serve as skin barriers.

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