Necrosis in chronic leg ulcers developed in all of the four patients who were treated topically with a fluocinolone acetonide-neomycin sulfate ointment. This was probably due to the vasoconstrictive properties of the steroid. A warning against the topical use of potent steroids in skin diseases wih impaired circulation seems to be justified.
BJORNBERG A, HELLGREN L. Necrosis in Leg Ulcers: Probable Role of Fluocinolone Acetonide. Arch Dermatol. 1965;92(1):52–53. doi:10.1001/archderm.1965.01600130058008
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