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July 1965

Leukoderma Acquisitum Centrifugum: An Unusual Case

Author Affiliations


From the Department of Laboratories, Long Island Jewish Hospital, New Hyde Park, NY; the Department of Dermatology, Columbia University, College of Physicians and Surgeons and the Dermatology Service, Presbyterian Hospital, New York (Dr. Shapiro). Department of Dermatology, New York University Schools of Medicine and the Oncology Section, Skin and Cancer Unit, University Hospital (Dr. Kopf).

Arch Dermatol. 1965;92(1):64-68. doi:10.1001/archderm.1965.01600130070013

A case is presented of a 9-year-old girl who developed a depigmented halo around a pigmented tumor of the skin on her shoulder. She also developed widespread metastases in the ipsilateral axillary lymph nodes, lungs, and, presumably, liver, and subsequently died of her disease. Histologic interpretations of the nature of the cutaneous tumor and axillary metastases are given and the suggestion made that the skin lesion was a malignant melanoma. Should this interpretation be correct, this case represents the first of its kind in which a lesion in a child with the clinical features of a halo nevus proved to be a fatal malignant melanoma.

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