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September 1965


Arch Dermatol. 1965;92(3):344-345. doi:10.1001/archderm.1965.01600150134031

Primary Cutaneous Amyloidosis. Presented by Capt Stephen B. Webster, MC, USA, and Crawford S. Brown, MD. 

History.—  A 56-year-old Chinese male has had a progressive pruritic eruption on the anterior aspect of his lower legs for 20 years. There are no lesions elsewhere nor are there symptoms of systemic amyloidosis.

Physical Examination.—  The skin over both lower legs reveals discrete brownish, slightly translucent, scaly papules, 1 to 2 mm in diameter. The papules are in close proximity, but are discrete.

Laboratory Findings.—  Biopsies of the kidney and liver showed no amyloid deposits but the crystal violet stain demonstrated amyloid infiltrating the corium.

Biopsy.—  The papillary corium showed depositions of amyloid material that stained with crystal violet.

Treatment.—  The discrete, dry papules and the intense itching have not responded to corticosteroid therapy applied topically or by vibra puncture. Symptomatic topical medication for itching is being used.

Discussion  Dr. John M. Siegel