Erythropoietic protoporphyria was observed in four related persons, and 20 cases from the literature were surveyed. In all cases sunlight was a major precipitating factor. Erythema and edema are early changes in this "solar urticaria" and a late eczematous stage occurs in some cases. Erythropoietic protoporphyrin was ten to 50 times normal levels in patients with signs and symptoms.
LYNCH PJ, MIEDLER LJ. Erythropoietic Protoporphyria: Report of a Family and a Clinical Review. Arch Dermatol. 1965;92(4):351–356. doi:10.1001/archderm.1965.01600160007002
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