Thirty-three patients suspected of having squamous cell carcinoma of the skin were studied to evaluate the systemic administration of tetracycline compounds as a screening test for detecting malignancy.
The results of this study confirm the affinity of tetracyclines for tumor tissue and indicate that the systemic administration of these compounds is a reliable and reproducible technique for the detection of squamous cell carcinoma of the skin. However, the value of this procedure remains limited since the tumor must be superficially located in the skin in order to demonstrate fluorescence.
DONSKY HJ. Tetracycline Fluorescence in Squamous Cell Carcinoma. Arch Dermatol. 1965;92(4):388–393. doi:10.1001/archderm.1965.01600160044007
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