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October 1965

Intracutaneous Injection of Sebum and Comedones: Histological Observations

Author Affiliations


From the Department of Dermatology and Evans Memorial Department of Clinical Research, University Hospital, Boston University Medical Center.

Arch Dermatol. 1965;92(4):443-456. doi:10.1001/archderm.1965.01600160099023

The injection of sebum and comedones into the human skin excites a lymphocytic inflammatory response. The free fatty acids in sebum are chiefly responsible for the observed inflammation. When the inflammation is quite marked, the pilosebaceous follicles undergo rupture, and strands of epithelium grow out to encapsulate the inflammatory mass. Giant cells, which may be present in the inflammatory response, appear to be the result of follicular collapse with the consequent liberation of follicular wall keratin and hair which act as foreign bodies. These histological changes are comparable to those occurring in acne.

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