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November 1965

CRST Syndrome: A Benign Variant of Scleroderma

Arch Dermatol. 1965;92(5):519-525. doi:10.1001/archderm.1965.01600170035006

Seven new cases of the CRST syndrome (calcinosis cutis, Raynaud's phenomenon, sclerodactylia, and telangiectasia resembling heredity hemorrhagic telangiectasia) are reported. This probable variant of systemic scleroderma is noteworthy because of the benign course it follows and its excellent prognosis for life expectancy. Such cases should be differentiated from hereditary hemorrhagic telangiectasia, since there is no true relationship between the two syndromes.