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November 1965

Letterer-Siwe Disease: Report of a Case Emphasizing Effective Corticosteroid Therapy

Author Affiliations


From the Department of Dermatology, University of Cincinnati Medical School (Dr. Goldberg), and Childrens Hospital (Dr. Diamond).

Arch Dermatol. 1965;92(5):561-565. doi:10.1001/archderm.1965.01600170077013

A case report of Letterer-Siwe disease has been presented in which a striking therapeutic response and remission was accomplished by adequate dosage of a corticosteroid. In this instance, soluble methylprednisolone sodium succinate accomplished the desired effect. The drug was administered in divided dosage of 20 mg every six hours to an eighteen-month-old infant for a period of time without any untoward incidence. In one form or another, the corticosteroid must be continued since treatment of this disease is empiric. Further, we believe that corticosteroids are a must in the treatment of this serious, acute, often fatal, multisystem disease. An indicated antibiotic should be given in adequate and sufficient dosage.

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