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November 1965

An Unusual Vasculitis Due to DiphenhydramineCutaneous and Central Nervous System Involvement

Arch Dermatol. 1965;92(5):577-580. doi:10.1001/archderm.1965.01600170093018

A 43-year-old Negro man, with atopic dermatitis of long standing, developed a super-imposed unrelated papular pruritic eruption and neurologic manifestations related to oral and parenteral intake of diphenhydramine. Immunologic, histopathologic, and clinical observations suggest a relationship of this observed vasculitis to diphenhydramine drug allergy.