The use of chemical solubility techniques in association with electron microscopy as a method of detecting silver and its compounds, or both in skin tissue has been reported. It was possible to determine that the silver containing particles in the case of localized argyria were silver sulfide. Moreover, the particles were present chiefly intracellularly, nucleated to the margin of oval structures or densely packed within such structures. The average size of the silver sulfide particles was 300 Angstrom units with a calculated mass of 1.035 × 10-16 grams.
BUCKLEY WR, OSTER CF, FASSETT DW. Localized ArgyriaII. Chemical Nature of the Silver Containing Particles. Arch Dermatol. 1965;92(6):697–705. doi:10.1001/archderm.1965.01600180089018
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