The known effect of griseofulvin on the metabolism of porphyrins in animals was confirmed in a case of porphyria cutanea tarda in an elderly man, to whom griseofulvin was given purposely to study the result—significant increases of fecal coproporphyrins were observed, more marked than in normal individuals. The increase of blood coproporphyrin was comparable to that observed in the normal controls. The level of blood lipids was unaffected by griseofulvin administration.
ZIPRKOWSKI L, SZEINBERG A, CRISPIN M, KRAKOWSKI A, ZAIDMAN J. The Effect of Griseofulvin in Hereditary Porphyria Cutanea Tarda: Investigation of Porphyrins and Blood Lipids. Arch Dermatol. 1966;93(1):21–27. doi:10.1001/archderm.1966.01600190027004
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