We have reviewed the search for adequate penicillin treatment in patients with active neurosyphilis. Only studies giving data obtained by spinal fluid examination were discussed. Most studies in which patients have been observed for an adequate length of time following treatment report a failure rate of approximately 10% within two years, regardless of the form or amount of penicillin given.
A study using benzathine penicillin G 4,800,000 units in patients with active neurosyphilis was reported. Twenty-six patients were treated: 23 were followed one year or more and 17 of these for two years or longer. Two patients failed to respond to this dosage. The results are comparable to those obtained with other schedules and forms of penicillin.
SHORT DH, KNOX JM, GLICKSMAN J. Neurosyphilis, the Search for Adequate Treatment: A Review and Report of a Study Using Benzathine Penicillin G. Arch Dermatol. 1966;93(1):87–91. doi:10.1001/archderm.1966.01600190093022
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