This non-corticoid steroid possesses potent local anti-inflammatory activity in animals. Study was therefore undertaken of its topical activity in humans. The negative results in man demonstrate a dichotomy in activity between species. However, in man, there was correlation between poor vaso-constrictor activity and lack of anti-inflammatory activity by this non-corticoid structure.
BRONSTEIN S, GRATER W, JACOBSON C, ORENTREICH N, APPLEZWEIG N. Human and Animal Anti-Inflammatory Activity of an Acetonide of Progesterone: Dichotomy of Results Between Man and Laboratory Animal with 16, 17-Dihydroxyprogesterone Acetonide. Arch Dermatol. 1966;93(1):114–118. doi:10.1001/archderm.1966.01600190120027
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