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Article
January 1966

Human and Animal Anti-Inflammatory Activity of an Acetonide of Progesterone: Dichotomy of Results Between Man and Laboratory Animal with 16, 17-Dihydroxyprogesterone Acetonide

Author Affiliations

MORRIS PLAINS, NJ; DALLAS; NEW YORK

From the Division of Clinical Research, Warner-Lambert Research Institute, Morris Plains, NJ.

Arch Dermatol. 1966;93(1):114-118. doi:10.1001/archderm.1966.01600190120027
Abstract

This non-corticoid steroid possesses potent local anti-inflammatory activity in animals. Study was therefore undertaken of its topical activity in humans. The negative results in man demonstrate a dichotomy in activity between species. However, in man, there was correlation between poor vaso-constrictor activity and lack of anti-inflammatory activity by this non-corticoid structure.

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