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February 1966

Candida Granuloma: Studies of Host-Parasite Relationships

Author Affiliations


From the Department of Medicine, Division of Dermatology, University of California, The Center for the Health Sciences and the Medical Service, Veterans Administration Center, General Medical and Surgical Hospital.

Arch Dermatol. 1966;93(2):149-161. doi:10.1001/archderm.1966.01600200005001

Candida granuloma, an unusual infection produced by Candida albicans, usually begins in early childhood and prior to the use of amphotericin B pursued an invariably chronic and progressive course. Immunologic abnormalities in the host have frequently been considered to be the essential predisposing factor for the development of this syndrome. This paper presents the results of studies of several parameters associated with host-parasite relationships in a patient with Candida granuloma. Special research and routine studies did not disclose any specific property of the fungus or defect in the defense mechanisms of the patient to account for the development of this disease. The concept of specific immunologic unresponsiveness is proposed to explain the patient's extreme susceptibility to the development of infection with C albicans.

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