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February 1966

Idiopathic Guttate Hypomelanosis

Author Affiliations


From the Charity Hospital of Louisiana, Tulane University School of Medicine, and Louisiana State University School of Medicine, New Orleans.

Arch Dermatol. 1966;93(2):184-186. doi:10.1001/archderm.1966.01600200040005

A new entity consisting of multiple, smooth, discrete, macular, off-white, hypopigmented lesions occurring on the upper and lower extremities and scattered areas on the trunk is described. By a random survey, the incidence of this dermatosis was found to be exceedingly high. Histologically, the skin appears normal except for the absence of melanin, and with the B-(3,4-dihydroxyphenyl)-L-alamine (dopa) stain there is decreased to absent dopa oxidase. Through analysis of patient histories, laboratory work, and a review of the literature a hypothesis as to etiology and relationship to other hypopigmenting disorders is discussed.

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