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February 1966


Author Affiliations

Department of Dermatology University of Oregon Medical School 3181 SW Sam Jackson Park Rd Portland, Ore 97201

Arch Dermatol. 1966;93(2):261. doi:10.1001/archderm.1966.01600200117025

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To The Editor:  The case report "Symmetric Acroleukopathy in Mother and Daughter" by Sugai, Saito, and Hamada in the August 1965 issue of the Archives of Dermatology, deserves careful consideration as regards classification.The clinical and histopathologic feature described in the article are surely those of vitiligo. The statement "No hyperpigmented area could be seen" is refuted by Fig 4 (case 2) in which hyperpigmented areas are demonstrated adjacent to depigmented ones (on the toes).The authors mentioned dopa-negative melanocytes in the depigmented skin. It would seem more appropriate to say there was absence of dopa-positive melanocytes, for they have not actually demonstrated the presence of melanocytes in the depigmented areas.Perhaps the authors regard their unusual cases as a form of vitiligo. If so, then the article should have been given a more appropriate title.For further discussion any agent which regulates cell activity as this anti template does

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