Twelve members of a single family were found to exhibit a disorder of keratinization. Seven of these persons had findings characteristic of Ackrokeratosis Verruciformis (Hopf), one member or possibly two had Darier's disease, and three of the family had minor disturbances of keratinization. It was proposed that these disorders represent variable manifestations of a single underlying genetic defect in keratin formation.
HERNDON JH, WILSON JD. Acrokeratosis Verruciformis (Hopf) and Darier's Disease: Genetic Evidence for a Unitary Origin. Arch Dermatol. 1966;93(3):305–310. doi:10.1001/archderm.1966.01600210041006
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