Sera from 25 patients with varying degrees of acne vulgaris and sera from 23 patients without acne were tested for antibody levels to Corynebacterium acnes using the complement-fixation test. Results indicate that levels of complement-fixing antibodies to C acnes are significantly higher in patients with acne than in control groups. Antigen prepared from disrupted C acnes was found to be reactive in the complement-fixation test.
PUHVEL SM, HOFFMAN IK, STERNBERG TH. Corynebacterium Acnes: Presence of Complement Fixing Antibodies to Corynebacterium acnes in the Sera of Patients With Acne Vulgaris. Arch Dermatol. 1966;93(3):364–366. doi:10.1001/archderm.1966.01600210100020
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