The intralesional use of corticosteroids is presently an important form of dermatologic therapy. A mixture of betamethasone disodium phosphate and betamethasone acetate has been evaluated after its intralesional use in certain dermatologic conditions. Five hundred twenty patients were treated and an average of 82% of these improved after injection. Two percent of the patients became worse while under treatment and of the entire group only five noted any type of adverse reaction. At the present time, this preparation appears to be one of the more valuable agents for local intralesional or sublesional dermatologic use. Clinically it compares favorably with other similar compounds and in this study systemic reactions were few and local complications were absent.
NOOJIN RO, OSMENT LS, DOUGLASS HJ. Intralesional Therapy With Betamethasone. Arch Dermatol. 1966;93(4):463–464. doi:10.1001/archderm.1966.01600220075024
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