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May 1966


Author Affiliations

Dermatology Branch National Cancer Institute

Arch Dermatol. 1966;93(5):633. doi:10.1001/archderm.1966.01600230137035

To the Editor:  Webster, Reister, and Harmon1 reported a case of juvenile xanthogranuloma with extracutaneous involvement which they believed to be the fourth recorded in the literature. Their patient, although asymptomatic, received a course of cardiac x-ray at age 7 months. Eller2 also has documented this case.Early treatment, however, may not be indicated in this syndrome. Lottsfeld and Good3 reported spontaneous regression of both cutaneous and visceral lesions over a four-year-period in a child with cutaneous and pulmonary xanthogranulomas. Xanthogranulomas also have been found in various organs without concomitant cutaneous lesions.4-8 These cases may represent instances where skin lesions have regressed but extracutaneous lesions have persisted.In view of the possibility of spontaneous regression it appears advisable that definitive therapy be avoided unless symptoms supervene.

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