In view of enthusiastic reports concerning the use of dimethyl sulfoxide in scleroderma, a clinical trial with this agent was carried out. Twenty-four patients with systemic scleroderma were treated with local applications of dimethylsulfoxide. Under the conditions of this study, no improvement of any of the parameters studied was noted.
TUFFANELLI DL. A Clinical Trial With Dimethyl Sulfoxide in Scleroderma. Arch Dermatol. 1966;93(6):724–725. doi:10.1001/archderm.1966.01600240090018
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