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June 1966

Human Low-Dosage Parenteral Methotrexate Therapy: A Controlled Toxicity Study

Author Affiliations


From the Dermatology Section, Medical Service, Wadsworth Hospital, Veterans Administration Center, Los Angeles, and the Department of Medicine, Division of Dermatology, UCLA Center for the Health Sciences, Los Angeles.

Arch Dermatol. 1966;93(6):731-736. doi:10.1001/archderm.1966.01600240097020

Methotrexate was administered intramuscularly to ten patients with severe psoriasis and one patient with a generalized erythroderma. All patients were observed carefully for toxicity by the use of a number of laboratory procedures. Clinical improvement was compared with a control group receiving placebo injections and standard dermatologic topical therapy. The results indicate that methotrexate administered intramuscularly is a therapeutically beneficial drug; however, it is a potentially toxic drug, unless precautions are observed.

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