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June 1966

Effect of Light and Hematoporphyrin on Immunologic Components of Human Sera

Author Affiliations


From the Division of Dermatology (Drs. Burnett and Swann) and the Department of Anatomy (Dr. Figge), University of Maryland School of Medicine, Baltimore.

Arch Dermatol. 1966;93(6):754-757. doi:10.1001/archderm.1966.01600240120024

The effects of light and hematoporphyrin on pooled human sera with elevated titers of antistreptolysin O, heterophil and "immune" anti-A antibodies, and high concentrations of rheumatoid factor were studied. In all experiments, the paper electrophoretic pattern of irradiated specimens containing porphyrin demonstrated a loss of definite globulin peaks and a decrease in albumins. Associated with this change was a reversal in the albumin/globulin (A/G) ratio in all specimens studied. Heterophil and immune anti-A antibodies were apparently very sensitive to light and hematoporphyrin, whereas the antistreptolysin O antibodies were not decreased. Hematoporphyrin caused nonspecific agglutination of latex particles. The combined action of light and porphyrins produced a striking and significant destruction of all three immune globulins.

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