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June 1966

Development of Antibodies in Response to Immunization With Heterologous Skin

Author Affiliations


From the Department of Dermatology, College of Physicians and Surgeons, Columbia University, and the Dermatology Service of the Presbyterian Hospital, NY.

Arch Dermatol. 1966;93(6):758-762. doi:10.1001/archderm.1966.01600240124025

Rabbits immunized with full-thickness human fetal skin developed circulating antibodies against antigen (s) in human epidermis. The antisera reacted with a common antigen in human esophagus and ileum but did not cross-react with tissues or serum obtained from other species. Evidence of the development of delayed hypersensitivity to antigens of human epidermis was equivocal. No cutaneous or visceral lesions developed in the animals studied during a 15-month period of observation.

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