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July 1966


Arch Dermatol. 1966;94(1):95-99. doi:10.1001/archderm.1966.01600250101023

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Keratosis Follicularis (Darier's Disease) Sudden Onset Following Pancreatectomy). Presented by Dr. Carl T. Nelson. 

History.—  The patient is a white man, age 59. In February 1965 the patient developed jaundice associated with elevation of the serum alkaline phosphatase and bilirubin levels. After suitable studies, a total pancreatectomy was performed on March 13, 1965, for carcinoma of the head of the pancreas. This operation included bilateral vagotomy, partial gastrectomy, jejunectomy, splenectomy, and cholecystectomy. The postoperative course was relatively easy except for difficulty in regulating the patient's diabetes. The jaundice cleared promptly. About one month after operation the patient noted the development of scattered keratotic papules on the trunk. These were relatively asymptomatic and did not enlarge appreciably, remaining about 2 mm to 5 mm in diameter.

Description.—  Since the initial eruptive appearance of these lesions there has been no progression. Some may have disappeared. On the trunk at the present time

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