A patient is presented who gave a history of cold hypersensitivity in childhood which had disappeared at the age of 8 years. This hypersensitivity in the form of cold urticaria reappeared only at the site of many hyposensitizing injections and was unassociated with any systemic disease. These observations suggest that the patient had somehow adapted to the cold hypersensitivity present in childhood. But ragweed injections affected the tissue being treated by altering the threshold to cold tolerance of one or more of the factors involved in histamine release. Tests with antihistamines, vasodilators, vasoconstrictors, histamine and its releasers, heparin, and an anesthetic did not alter his abnormal response to cold.
SOLOMON LM, STRAUSS H, LEZNOFF A. Localized "Secondary" Cold Urticaria. Arch Dermatol. 1966;94(2):156–160. doi:10.1001/archderm.1966.01600260048005
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