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Article
August 1966

CHICAGO DERMATOLOGICAL SOCIETY

Arch Dermatol. 1966;94(2):236-249. doi:10.1001/archderm.1966.01600260128022

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Abstract

Dermatitis Herpetiformis and Hypothyroidism. Presented by Adolph Rostenberg, Jr., MD, David Fretzin, MD, and Dean Dimmick, MD.  The patient is a 47-year-old married male, electrician, on whom in 1959, following symptoms of fatigue, weight gain, and hoarseness of voice, a diagnosis of hypothyroidism was made. He was placed on thyroid extract with clinical improvement within four weeks. However, by the sixth week he had developed a pruritic vesiculobullous eruption over the extensor surfaces of his arms and legs, with some lesions of the scalp and neck. This was initially felt to be a drug reaction from the thyroid medication, and the thyroid extract was discontinued, with clearing of the skin lesions. One month later he was given a trial of thyroglobulin (Proloid) with the development of the same skin lesions in four to six weeks. These again cleared with discontinuation of the thyroid medication. Subsequent trials of

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