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August 1966


Author Affiliations

Department of Dermatology Osaka City University Medical School 1-61, Asahi, Abeno Osaka, Japan

Arch Dermatol. 1966;94(2):252. doi:10.1001/archderm.1966.01600260144024

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To the Editor:  In regard to the comment of Drs. Saunders and Hu (Arch Derm93:261, 1966) that hyperpigmented areas adjacent to the depigmented ones can be seen on the toes shown in Fig 4 (case 2; Arch Derm92:172, 1965), we assure you that there are no hyperpigmented areas on the surrounding regions.Normally distributed, dopa-negative clear cells were found in the basal layer of depigmented areas in sections counterstained with hemotoxylin and eosin. Although we did not show any direct evidence for the presence of melanocytes in the depigmented areas with specific techniques, it is our opinion that basal clear cells are epidermal melanocytes themselves. This opinion is supported by massive data found in sections of vitiliginous lesions stained with a modified silver impregnation of Suzuki, osmiumiodide, and methylene blue supravital staining technique.

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