A 29-year-old man with vitiligo was treated by sympathectomy and later by racemized α-melanin-stimulating hormone (MSH). Only a slight increase in melanogenic activity of normal skin followed sympathectomy, while the vitiligo progressed. Alpha-MSH produced darkening and melanocytic activity in normal skin, but vitiliginous areas were unaffected.
LERNER AB, SNELL RS, CHANCO-TURNER ML, McGUIRE JS. Vitiligo and Sympathectomy: The Effect of Sympathectomy and a-Melanocyte Stimulating Hormone. Arch Dermatol. 1966;94(3):269–278. doi:10.1001/archderm.1966.01600270019004
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