Six cases of Reiter's syndrome are reported. All had severe arthritis and keratosis blennorrhagica unsuccessfully managed by penicillin, antimalarials, and/or systemic corticoids. Folic acid antagonists proved effective in controlling the cutaneous manifestations. The joint symptoms, however, proved more recalcitrant in some of the cases.
MULLINS JF, MABERRY JD, STONE OJ. Reiter's Syndrome Treated With Folic Acid Antagonists. Arch Dermatol. 1966;94(3):335–339. doi:10.1001/archderm.1966.01600270085019
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