An epidermal compound which inhibits melanin formation was described by Rothman et al in 1946. Evidence indicating that this compound is reduced glutathione is presented. The concentration of this compound and of glutathione reductase is higher in white epidermis than Negro epidermis. The implications of these findings in understanding the control of human pigmentation are discussed.
HALPRIN KM, OHKAWARA A. Glutathione and Human Pigmentation. Arch Dermatol. 1966;94(3):355–357. doi:10.1001/archderm.1966.01600270105022
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