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October 1966

Tuberculin-Type Reaction to Heparin-Chromium Complex: Heparin—A Specific Carrier of Chromium Sensitivity

Author Affiliations


From the Department of Dermatology and Venerology, Hadassah-University Hospital and Hebrew University Hadassah Medical School, Jerusalem, Israel.

Arch Dermatol. 1966;94(4):409-412. doi:10.1001/archderm.1966.01600280027005

Thirty-seven patients suffering from contact dermatitis to potassium bichromate showed positive intradermal reactions with chromium chloride and with complexes prepared in vitro of human serum albuminchromium chloride and heparin-chromium chloride.

With γ-globulin-chromium chloride complex the reaction was inhibited in 26 out of the 37 patients. Eleven patients gave weak transient reactions. The reaction was inhibited in eight sensitive patients tested with rabbit's liver glycogen-chromium chloride complex.

Thirty-seven control individuals not suffering from potassium bichromate sensitivity did not react positively to chromium chloride or to any of the above mentioned complexes. It is noted that there was no difference in carrier specificity between human serum albumin and heparin. This observation suggests that in chromium sensitivity occurring naturally in humans, heparin might act as a carrier for chromium cation.

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