Thirty-seven patients suffering from contact dermatitis to potassium bichromate showed positive intradermal reactions with chromium chloride and with complexes prepared in vitro of human serum albuminchromium chloride and heparin-chromium chloride.
With γ-globulin-chromium chloride complex the reaction was inhibited in 26 out of the 37 patients. Eleven patients gave weak transient reactions. The reaction was inhibited in eight sensitive patients tested with rabbit's liver glycogen-chromium chloride complex.
Thirty-seven control individuals not suffering from potassium bichromate sensitivity did not react positively to chromium chloride or to any of the above mentioned complexes. It is noted that there was no difference in carrier specificity between human serum albumin and heparin. This observation suggests that in chromium sensitivity occurring naturally in humans, heparin might act as a carrier for chromium cation.
COHEN HA. Tuberculin-Type Reaction to Heparin-Chromium ComplexHeparin—A Specific Carrier of Chromium Sensitivity. Arch Dermatol. 1966;94(4):409–412. doi:10.1001/archderm.1966.01600280027005
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