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October 1966

Reduced Growth Rates of Hair in Mice Following Radiation

Author Affiliations


From the Department of Medicine, Section of Dermatology, and Department of Radiology, Argonne Cancer Research Hospital, Chicago.

Arch Dermatol. 1966;94(4):491-498. doi:10.1001/archderm.1966.01600280109018

Anagen mouse hairs treated with single doses of x-rays ranging from 200-800 rads showed postradiation growth impairment as determined by overall hair length measurements. Reductions in hair lengths were dose-dependent and ranged from 8.3%-13.4%.

When telogen mouse hairs were exposed to single doses of 500-1500 rads and immediately plucked, the succeeding anagen hairs showed dose-dependent reductions in hair length of 5.1%-12.7%.

The presumed cellular changes responsible for radiation induced growth impairment are discussed.

The possible usefulness of hair growth rate measurements for investigation of a variety of radiobiological phenomena is described. Emphasis is placed on the related changes of radiation injury and recovery in hair. In particular, further studies of recovery processes may elucidate additional knowledge of the mechanism of radiation damage with useful applications for radiotherapy.

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