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Article
October 1966

Monographs in Allergy, vol 1: Immunotolerance to Simple Chemicals

Arch Dermatol. 1966;94(4):529. doi:10.1001/archderm.1966.01600280147029

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Abstract

This is both a review of the fundamentals of contact sensitivity and a presentation of the authors' own studies of tolerance to contact sensitizers. It deals only indirectly with contact dermatitis in man.

As a review, it is well organized, impartial, and thorough (though, as all books, not quite up to date). It is valuable both as a textbook and as a source-book to anyone interested in contact sensitivity or in tolerance.

The raison d'être of this book, however, is the presentation of original and methodical investigations of unresponsiveness to contact sensitizers, which the authors have induced in the guinea pig by intravenous administration of the antigen. This new information has significant bearing on our changing concepts of immunological tolerance.

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