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October 1966

Monographs in Allergy, vol 2: Tissue Mast Cells in Immune Reactions

Arch Dermatol. 1966;94(4):529. doi:10.1001/archderm.1966.01600280147030

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This monograph brings to the reader another detailed critical review of the world's literature on the role of the tissue mast cell in anaphylaxis as seen in animals, as well as in man. More significantly, it presents a comprehensive summary of a decade of distinguished research (more than 45 papers) the author has done using a quantitative in vitro rat mast cell system. Although the investigations were made in large part in the Department of Dermatology, University of Zurich, Dr. Keller's work and theorizing are of such a fundamental nature as to be of little concern to the clinical dermatologist. No unifying "field theory" evolves. Indeed, the author appears overwhelmed by our current ignorance of mediators and mechanisms, by the inexplicable species differences, and by the limitless complexity of the subject. Seven hundred and ninety often conflicting references support such an attitude. Nonetheless, Keller does suggest that active anaphylaxis in

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