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November 1966

Localized Scleroderma: A Histochemical and Chemical Study

Author Affiliations


From the Section of Dermatology, Department of Medicine, Hahnemann Medical College, Philadelphia.

Arch Dermatol. 1966;94(5):531-535. doi:10.1001/archderm.1966.01600290005001

A case of linear and morphea scleroderma is reported. Histochemical studies revealed an increase of positive PAS material, diastase resistant, in the areas of homogenized collagen. Chemical analysis suggests an increase in hexoses and hexosamines, probably bound to the collagen fibers.