College students in an organic chemistry laboratory preparing 9-bromofluorene from N-bromosuccinimide and fluorene developed erythema multiforme bullosum. This reaction took place 9 to 21 days following exposure in 24 of the 250 students who performed the experiment. The dermatitis began on exposed areas but rapidly involved covered portions of the body. Initially there were classical target lesions which coalesced leaving large denuded areas. Those affected developed elevated temperatures but were not particularly ill.
DeFEO CP. Erythema Multiforme Bullosum Caused by 9-Bromofluorene. Arch Dermatol. 1966;94(5):545–551. doi:10.1001/archderm.1966.01600290019004
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