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November 1966

Pityriasis Rubra Pilaris: Treatment With Folic Acid Antagonists

Author Affiliations


From the Section of Dermatology, Mayo Clinic and Mayo Foundation (Dr. Perry), and Mayo Graduate School of Medicine, University of Minnesota (Dr. Brown), Rochester.

Arch Dermatol. 1966;94(5):636-638. doi:10.1001/archderm.1966.01600290110019

Four patients with pityriasis rubra pilaris were treated with the oral form of folic acid antagonists (aminopterin and methotrexate) for an average duration of 12 months. Marked clinical improvement was noted in all four patients. Two patients have discontinued therapy for periods of 24 and 7 months and have not had a recurrence of their disease.

The pharmacology of folic acid antagonists and the rationale for their use in the treatment of pityriasis rubra pilaris are briefly discussed.

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