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December 1966

Bloom's Syndrome: The Syndrome of Telangiectatic Erythema and Growth Retardation

Author Affiliations


From the Department of Medicine, Division of Dermatology (Drs. Landau and Newcomer) and the Department of Radiology (Drs. Sasaki and Norman), University of California at Los Angeles School of Medicine, Los Angeles.

Arch Dermatol. 1966;94(6):687-694. doi:10.1001/archderm.1966.01600300011003

Bloom's syndrome is a genodermatosis characterized by a telangiectatic erythema of the face beginning in infancy, sensitivity to sunlight, small stature, and a low birth weight after a full-term gestation. A structural chromosome abnormality and an increased incidence of leukemia are associated. A classical example of this syndrome is presented in a patient who also exhibited low yA and γM levels in the serum. Bloom's syndrome is compared with four other syndromes that have some similarity to it: Rothmund-Thomson syndrome, Cockayne's syndrome, ataxiatelangiectasia, and dyskeratosis congenita. These syndromes may be unrelated or may represent variants of the same underlying condition.