[Skip to Navigation]
Article
December 1966

Cutaneous Aspects of the XXYY Genotype: A Variant of Klinefelter's Syndrome

Author Affiliations

MINNEAPOLIS

From the Divisions of Dermatology and Oral Pathology, University of Minnesota, Minneapolis (Drs. Peterson and Gorlin); the Department of Oral Surgery, Howard University, Washington, DC (Dr. Peagler); and the Department of Pediatrics, Minnesota State School, Faribault.

Arch Dermatol. 1966;94(6):695-698. doi:10.1001/archderm.1966.01600300019004
Abstract

Five individuals with a variant of Klinefelter's (XXYY) syndrome are presented. The characteristics of the syndrome are discussed, including those signs of interest to dermatology. They include variations in body hair, lack of acne at adolescence, multiple cutaneous angiomas, acrocyanosis, and peripheral vascular disease producing the early onset of stasis dermatitis. The stasis change resembles that found in patients of normal genotype both clinically and histologically. The various effects of androgens and estrogens on peripheral vasculature are discussed.

Add or change institution
×