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Article
December 1966

The Basement Membrane in Relation to Carcinoma of the Skin

Author Affiliations

CHARLOTTESVILLE, VA

From the Department of Dermatology and the Department of Pathology, University of Virginia School of Medicine, Charlottesville, Va.

Arch Dermatol. 1966;94(6):712-715. doi:10.1001/archderm.1966.01600300036007
Abstract

The histochemically demonstrable basement membrane marking the epidermaldermal junction is usually normal in the epidermal carcinomas in situ, whereas in the invasive epidermoid carcinomas it is, in most instances, severely disrupted. However, nests of invading cells and metastatic foci in lymph nodes may show basement membranes, so that presence or absence of the structure is not an absolute criterion for invasiveness.

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