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Article
December 1966

The Experimental Production of Drug Phototoxicity in Guinea Pigs: II. Using Artificial Light Sources

Author Affiliations

SAN FRANCISCO

From the Dermatology Research Section, Research and Development Service, Letterman General Hospital, San Francisco. Dr. Sams is now at the Mayo Clinic in Rochester, Minn.

Arch Dermatol. 1966;94(6):773-777. doi:10.1001/archderm.1966.01600300097019
Abstract

Phototoxicity to chlorpromazine has been demonstrated in guinea pigs. This phototoxic reaction, characterized by erythema and necrosis of the ears, is produced regularly and easily. The source of ultraviolet was either a bank of fluorescent ultraviolet lamps or a high-pressure mercury vapor lamp. Phototoxicity was demonstrable only when a tough transparent plastic (Mylar) was interposed between the light source and the experimental animals. Without the plastic, the phototoxic response was masked by the normal erythema.

It was not possible to consistently demonstrate phototoxicity to demethylchlortetracycline or chlorothiazide using these methods.

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