Acetylcholine- and methacholine-induced sweating was quantitated over time. Acetylcholine produces sweat more rapidly and more evanescently than methacholine. Methacholine-induced sweating is delayed initially but is prolonged. Amounts of sweat are not always drug-concentration dependent.
Sex differences were quantitated. In agreement with previous studies, men consistently produced more sweat than women.
Repeated methacholine injections failed to produce a depression in sweating (hidromeiosis). To the contrary, increased amounts of sweat were noted (sweat-gland training).
GORDON BI, MAIBACH HI. Studies of Acetylcholine- and Methacholine-Induced Sweating. Arch Dermatol. 1966;94(6):778–781. doi:10.1001/archderm.1966.01600300102020
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