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December 1966

Studies of Acetylcholine- and Methacholine-Induced Sweating

Author Affiliations


From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco.

Arch Dermatol. 1966;94(6):778-781. doi:10.1001/archderm.1966.01600300102020

Acetylcholine- and methacholine-induced sweating was quantitated over time. Acetylcholine produces sweat more rapidly and more evanescently than methacholine. Methacholine-induced sweating is delayed initially but is prolonged. Amounts of sweat are not always drug-concentration dependent.

Sex differences were quantitated. In agreement with previous studies, men consistently produced more sweat than women.

Repeated methacholine injections failed to produce a depression in sweating (hidromeiosis). To the contrary, increased amounts of sweat were noted (sweat-gland training).

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