The effect of topically applied 5-fluorouracil on epithelialization of shallow wounds was studied. The drug delayed epithelialization of wounds in each of 11 subjects compared to the control ointments. In no case did the drug alter normal intact skin. Counts of mitoses in the epidermis at wound margins revealed a significant inhibition of mitosis associated with 5-fluorouracil treatment. It is proposed that the specific effect of 5-fluorouracil on cutaneous neoplastic lesions is related to selectively greater absorption of the agent in diseased skin compared to adjacent normal skin.
WALDORF DS, ENGEL ML, VAN SCOTT EJ. Inhibition of Wound Epithelialization by Topical 5-Fluorouracil. Arch Dermatol. 1966;94(6):786–789. doi:10.1001/archderm.1966.01600300110022
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: