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December 1966


Arch Dermatol. 1966;94(6):797-809. doi:10.1001/archderm.1966.01600300121025

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Chronic Lymphatic Leukemia: Cutaneous Necrosis. Presented by Theodore Cornbleet, MD, and G. C. Brual. 

History.—  A 77-year-old white woman was hospitalized seven months ago for weakness, loss of weight, and anemia. Upon subsequent hematologic work-up a diagnosis of chronic lymphocytic leukemia was made and she was treated with cyclophosphamide (Cytoxan), 150 mg, and prednisone, 40 mg, daily in divided doses. She was also given blood transfusion. She was readmitted a month ago for spiking fever, cough, and syncope.The skin lesions developed four weeks ago, starting as small vesiculopustules on the right paranasal area. They became confluent and enlarged peripherally. The lips and mucous membranes were later involved.

Pertinent Physical Findings.—  There was an erosion on the right paranasal area measuring 2 × 3 cm, with dried, brownish-black crusts; crusts and erosions on the lips and mucous membranes; shotty submandibular adenopathy. Moist rales were heard at the left lung base.

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