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December 1966


Arch Dermatol. 1966;94(6):809. doi:10.1001/archderm.1966.01600300133026

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Epidermolysis Bullosa Simplex, Hereditary Dominant Type. Presented by Murray C. Zimmerman, MD. 

History.—  A 12-year-old boy, an only child, was seen April 19, 1966. He stated that he had had "blisters" on his skin present since birth, developing at any point of minor trauma. He had never been free of them. His father stated that he had had the same symptoms for life; his lesions had spontaneously improved as he became older and are now much less severe than they were when he was the age of his son. The grandparents were symptomfree as were seven siblings.

Physical Examination.—  He was poorly developed, 144.8 cm (4 ft 9 inches) tall, weighed 36.7 kg (81 lb), very intelligent, and had bullae up to 3 cm diameter (more than one half of them containing pus rather than vesicle fluid) distributed mainly on major areas of trauma. There were multiple old areas of

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