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January 1967

Allergic Vasculitis Gougerot-Ruiter Syndrome: Immunofluorescent Study

Author Affiliations


From the departments of dermatology of the Instituto de Investigaciones Médicas, Hospital Tornú (Dr. Stringa), and the Policlínico de Avellaneda (Drs. C. Bianchi, Casala, and O. Bianchi), Buenos Aires.

Arch Dermatol. 1967;95(1):23-27. doi:10.1001/archderm.1967.01600310029005

The immunofluorescent technique was used to determine the presence of immuno-γ-globulin (IgG) and complement (C′3) in allergic vasculitis (AV) skin lesions. By the use of specific antisera it was possible to demonstrate that IgG and C′3 are present in the areas of fibrinoid necrosis of capillaries and small vessels in the corium. The presence of IgG and complement and the absence of other plasma proteins suggest that an immunologic process is taking place in the pathogenesis of AV. Similarity between these findings and those demonstrated in experimentally-induced Arthus phenomenon has been considered.

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