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January 1967

Effect of Dactinomycin on Pathogenic Fungi: With Special Reference to Experimental Cryptococcosis

Author Affiliations


From the Mycology Research Laboratory, Division of Medicine, Montefiore Hospital and Medical Center, Bronx, NY.

Arch Dermatol. 1967;95(1):124-130. doi:10.1001/archderm.1967.01600310130030

Epidermophyton floccosum grown on Sabouraud's glucose agar containing dactinomycin did not become pleomorphic for nine weeks in contrast to cultures grown on Sabouraud's glucose agar alone, which became pleomorphic in three weeks. Growth of E floccosum and Cryptococcus neoformans was inhibited, whereas no inhibition was observed on the growth of Microsporum canis, M gypseum, and Candida albicans. However, macroconidia of M canis, M gypseum, and E floccosum were studied. While the growth of Cr neoformans was inhibited by dactinomycin in concentration between 15 μg/ml and 100 μg/ml, the drug had no therapeutic effect in experimental cryptococcosis. One control mouse survived 50 days, whereas the rest died of the infection in five to seven days. The difference between the histopathological changes of the mouse which survived and the one which did on the fifth day are reported.